Why determine the tissue of origin?

When tumor origins are known, patient outcomes and even survival1 can improve. This is because oncologists have better information on which to base treatment strategies and can allow patients to benefit from today's advanced tumor-specific treatments.

It has been shown that metastatic tumors respond to tumor-specific therapies, which in some cases may even be curative.2  Even if not cured, some patients can experience other important benefits:

  • More tolerable and effective treatment options
  • Less necessity for repeated imaging tests (and less exposure to contrast agents)
  • Less time spent in travel or in medical facilities for testing, examinations, or repeated biopsy procedures
  • Less exposure to broad-spectrum chemotherapy regimens that may be more toxic and ineffective
  • Less emotional and financial burden on patients and caregivers
  • Opportunities for patients to enter appropriate clinical trials
  • New information for family members in assessing their familial risk for cancer

Learn how tissue-specific therapies have helped to change cancer treatment.

References

1. Abbruzzese JL, Abbruzzese MC, Lenzi R, Hess KR, Raber MN. Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin. J Clin Oncol. 1995;13:2094-103.
2. Briasoulis E, Pavlidis N. Cancer of unknown primary origin. Oncologist. 1997;2:142-152.
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